Editing Nobel Prize (section)

=== Why It Matters ===
This breakthrough unlocked one of immunology’s greatest mysteries — how the body maintains self-tolerance. Their work forms the foundation of treatments for '''autoimmune diseases, organ transplant rejection, and cancer immunotherapy'''.

Sakaguchi’s discovery of T-reg cells in the 1990s, later refined by Brunkow and Ramsdell, has led to clinical therapies that retrain the immune system rather than suppress it.
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